Liver health vitamins that help detoxify the entire body
The liver is responsible for storing vitamin B12 and folic acid (vitamin B9). Vitamin B12 promotes healthy liver function by promoting increased levels of syntaxin 17 (STX17), an autophagosomal SNARE protein that supports the liver’s ability to digest fat and regulate healthy inflammatory pathways.
“The liver takes a three-phase approach to its function, focusing on detoxification and organ support,” Dinets explains. “In Phase 1, fat-soluble substances and toxins circulate to boost metabolism. B vitamins enhance the function of liver enzymes called P450 enzymes, and glutathione and amino acids help regulate them.”*
B vitamins also help in phase 2, according to Dinets: “During this phase, the slightly more water-soluble substances from phase 1 are conjugated and broken down by methylation with methylfolate, a form of vitamin B9. Amino acid conjugation involving taurine, glutamine and NAC helps bind toxins. The excretion products then become more soluble in water for excretion in urine and feces.”*
So, are B vitamins good for the liver? Overall, research shows that B12 can support liver health—it regulates fat-soluble vitamins and helps filter toxins that don’t belong in the body. Folic acid is also critical for healthy methylation, which subsequently supports healthy liver function and overall detoxification.