Well, berberine is an ancient remedy with some modern research behind it. But it does actually work to lose weight? For some people, maybe. “Berberine has been linked to potential weight loss, although the scientific evidence to support this is still limited,” says Vinajmuri.

One review study reported that berberine can significantly affect the level of glucose in the blood4insulin sensitivity and inflammatory markers for those with metabolic disorders, improved body composition, and decreased triglycerides, total cholesterol, LDL, and increased HDL.

In another randomized, double-blind, placebo-controlled clinical trial in 24 patients diagnosed with metabolic syndrome, taking 500 mg of berberine three times a day (i.e., 1,500 mg/day) for three months resulted in significant reduction in waist circumference5systolic blood pressure and triglycerides, as well as increased insulin sensitivity.

Thus, although studies have shown that berberine has some promise in the area of ​​weight loss, it has mainly been studied in those who already had metabolic diseases such as Type 2 diabetes6.

In other words, it’s not guaranteed to help anyone lose weight. Another thing experts agree on is that while berberine may play a role in weight loss for some, it’s definitely not a substitute for a healthy diet and regular exercise. Also, berberine should not be taken as a “treatment” for metabolic diseases without consulting a doctor.